Tocris现货代理 Tocris GPCR ligands,Tocris/PFI 1/4445/10/10 mg,多肽,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PFI 1/4445/10/10 mg

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Tocris Bioscience

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4445/10

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4000-520-616

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Description:BETbromodomaininhibitor

ChemicalName:2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentBETbromodomaininhibitor;exhibitsinhibitoryactivityatbromodomain-containingprotein(BRD)2andBRD4(IC₅₀valuesare98and220nMrespectively).InducesapoptosisandG₁cellcyclearrestinBETinhibitor-sensitivecelllines(MV4;11).AlsodownregulatesAuroraBexpressioninMV4;11cells.Cellpermeable.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI1probesummaryontheSGCwebsite.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofPFI1isreviewedonthechemicalprobeswebsite.

CompoundLibraries

PFI1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	347.39
Formula	C₁₆H₁₇N₃O₄S
Storage	StoreatRT
Purity	≥98%(HPLC)
CASNumber	1403764-72-6
PubChemID	71271629
InChIKey	TXZPMHLMPKIUGK-UHFFFAOYSA-N
Smiles	O=C2NC1=CC=C(NS(C3=CC=CC=C3OC)(=O)=O)C=C1CN2C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	17.37	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight347.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.88mL	14.39mL	28.79mL
5mM	0.58mL	2.88mL	5.76mL
10mM	0.29mL	1.44mL	2.88mL
50mM	0.06mL	0.29mL	0.58mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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