BiologicalActivity
Potentandselectivepolybromo1andSMARCA4inhibitor(Kdvaluesare48and89nMrespectively).AlsoinhibitsSMARCA2.Displays30-foldselectivityoverothersub-familybranches.AcceleratesFRAPrecoveryincellsataconcentrationof1μM.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI3probesummaryontheSGCwebsite.
CompoundLibraries
PFI3isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 321.37 |
| Formula | C19H19N3O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1819363-80-8 |
| PubChemID | 78243717 |
| InChIKey | INAICWLVUAKEPB-QSTFCLMHSA-N |
| Smiles | O=C(C3=C(O)C=CC=C3)/C=C/N1[C@H](C4)CN(C2=NC=CC=C2)[C@H]4C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.14 | 100 | |
| ethanol | 1.61 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight321.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.11mL | 15.56mL | 31.12mL |
| 5mM | 0.62mL | 3.11mL | 6.22mL |
| 10mM | 0.31mL | 1.56mL | 3.11mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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