进口Tocris品牌清关代理 Tocris离子通道调控剂,Tocris/PFI 4/5576/50/50 mg,多肽,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PFI 4/5576/50/50 mg

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Tocris Bioscience

货号 /

5576/50

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4000-520-616

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Description:PotentandselectiveBRPF1bromodomaininhibitor

ChemicalName:N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveBRPF1bromodomaininhibitor(IC₅₀=80nM).Exhibits>100-foldselectivityforBRPF1overapanelofotherbromodomainsincludingBRPF2(BRD1),BRPF3andBRD4.DisruptsBRPF1bindingtohistoneH3.3.Cellpermeable.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI4probesummaryontheSGCwebsite.

CompoundLibraries

PFI4isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	380.44
Formula	C₂₁H₂₄N₄O₃
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	900305-37-5
PubChemID	40642506
InChIKey	QCIJLRJBZDBVDB-UHFFFAOYSA-N
Smiles	CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	19.02	50
	ethanol	3.8	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight380.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.63mL	13.14mL	26.29mL
5mM	0.53mL	2.63mL	5.26mL
10mM	0.26mL	1.31mL	2.63mL
50mM	0.05mL	0.26mL	0.53mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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