BiologicalActivity
BETbromodomaininhibitor(Kdvaluesare160,170,380,490,830and850nMforBRD4(1),BRD2(1),BRD3(1),BRD3(2),BRD2(2)andBRD4(2)respectively).AlsoinhibitsBRDT(1),CBP,p300andBRDT(2)(Kdvaluesare1.2,1.6,2.6and3.7μMrespectively).AttenuatesproliferationofHL-60leukemiacellsinvitro.
CompoundLibraries
XD14isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 421.51 |
| Formula | C20H27N3O5S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1370888-71-3 |
| PubChemID | 52670832 |
| InChIKey | DPBKLIVPNYGQQG-UHFFFAOYSA-N |
| Smiles | CC1=C(C(C)=O)C(CC)=C(C(NC2=CC(S(N(CC)CC)(=O)=O)=CC=C2O)=O)N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.15 | 100 | |
| ethanol | 42.15 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight421.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.37mL | 11.86mL | 23.72mL |
| 5mM | 0.47mL | 2.37mL | 4.74mL |
| 10mM | 0.24mL | 1.19mL | 2.37mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |
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