BiologicalActivity
PotentandselectiveinhibitorofregulatorofG-proteinsignaling4(RGS4)protein(IC50valuesare30.1nMand11.0μMforRGS4andRGS8respectively).Exhibits>20-foldselectivityforRGS4overotherRGSproteins.
CompoundLibraries
CCG50014isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 316.35 |
| Formula | C16H13FN2O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 883050-24-6 |
| PubChemID | 2733079 |
| InChIKey | QUIIIYITNGOFEI-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=CC=C3CN(C(N(C2=CC=C(C)C=C2)S1)=O)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight316.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.16mL | 15.81mL | 31.61mL |
| 5mM | 0.63mL | 3.16mL | 6.32mL |
| 10mM | 0.32mL | 1.58mL | 3.16mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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