BiologicalActivity
Novelinhibitorofheatshockprotein90(Hsp90)ATPaseactivity(IC50=5.7μM)thatdisplaysselectivityoverhumanHsp72andtopoisomeraseII.InhibitsproliferationofHCT116humancolontumorcellsandproducesupregulationofHsp70anddownregulationofc-Rafandcdk4.Moresolublethan17-AAG(Cat.No.1515)andisindependentofNQO1/DT-diaphoraseandP-glycoproteinexpression.
CompoundLibraries
CCT018159isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 352.39 |
| Formula | C20H20N2O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 171009-07-7 |
| PubChemID | 5327091 |
| InChIKey | BBTMGPQSLSYPHE-ZHZULCJRSA-N |
| Smiles | CCC1=C(O)C=C(O)C(=C1)C1=NNC(C)=C1C1=CC2=C(OCCO2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.24 | 100 | |
| ethanol | 35.24 | 100 | |
| water | 1.76 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight352.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.84mL | 14.19mL | 28.38mL |
| 5mM | 0.57mL | 2.84mL | 5.68mL |
| 10mM | 0.28mL | 1.42mL | 2.84mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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