BiologicalActivity
Heatshockfactor(HSF)inhibitor(IC50=1.2μM).IncreasesapoptosisincancercellstreatedwiththeHSP90inhibitorsGeldanamycin(Cat.No.1368)and17-AAG(Cat.No.1515).BlocksdownstreaminductionofHSP27andHSP70.Inhibitstumorgrowthinvivo.
TechnicalData
| M.Wt | 284.27 |
| Formula | C13H12N6O2 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 342639-96-7 |
| PubChemID | 69894253 |
| InChIKey | NDJJEQIMIJJCLL-UHFFFAOYSA-N |
| Smiles | CNC1=NC(NC2=CC=C(NN=C3)C3=C2)=C([N+]([O-])=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.43 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight284.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.52mL | 17.59mL | 35.18mL |
| 5mM | 0.7mL | 3.52mL | 7.04mL |
| 10mM | 0.35mL | 1.76mL | 3.52mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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