BiologicalActivity
Occupiesmortalin-2(mot-2),amemberoftheHsp70family,atitsp53bindingsiteandenablesp53translocationtothenucleus.Selectivelycytotoxic;causesgrowtharrestofcancercellsinculture.Alsoinhibitstelomeraseactivityandcross-linksF-actin.
CompoundLibraries
MKT077isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 432 |
| Formula | C21H22ClN3OS2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 147366-41-4 |
| PubChemID | 3037933 |
| InChIKey | VSKYOTRJSLYFHX-UXJRWBAGSA-M |
| Smiles | CN(C1=CC=CC=C1S2)/C2=C4/C(N(CC)/C(S4)=CC3=CC=CC=[N+]3CC)=O.[Cl-] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.6 | 50 | |
| water | 21.6 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight432.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.31mL | 11.57mL | 23.15mL |
| 5mM | 0.46mL | 2.31mL | 4.63mL |
| 10mM | 0.23mL | 1.16mL | 2.31mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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