BiologicalActivity
Noveladenosine-derivedinhibitorofHeatShockProtein70(Hsp70)(IC50=0.5μM).Inhibitscellproliferationofmultiplehumantumorcelllinesinvitro.AlsobindsHsc70andGrp78;displaysselectivityagainstHsp90β(IC50>200μMforHsp90β).
CompoundLibraries
VER155008isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 556.4 |
| Formula | C25H23Cl2N7O4 |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1134156-31-2 |
| PubChemID | 25195348 |
| InChIKey | ZXGGCBQORXDVTE-UMCMBGNQSA-N |
| Smiles | NC1=NC=NC2=C1N=C(NCC5=CC=C(Cl)C(Cl)=C5)N2[C@@H]3O[C@H](COCC4=CC=C(C#N)C=C4)[C@@H](O)[C@H]3O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight556.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.8mL | 8.99mL | 17.97mL |
| 5mM | 0.36mL | 1.8mL | 3.59mL |
| 10mM | 0.18mL | 0.9mL | 1.8mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |
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