BiologicalActivity
DOCK2-Rac1interactioninhibitor;suppressesDOCK2-inducedRac1activation.AlsoinhibitsDOCK1andDOCK5.ExhibitsselectivityoverDOCK9.Reduceschemotacticresponsesinvitroandinvivo,andactivatesTcellsinvitro.AlsoattenuatesHER2-mediatedbreastcancercellmigrationinvitro.
TechnicalData
| M.Wt | 324.76 |
| Formula | C18H13ClN2O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 310460-39-0 |
| PubChemID | 2248187 |
| InChIKey | VVZJFICTTKPNCK-XWDZFIQBSA-N |
| Smiles | O=C(N(C3=CC=CC=C3)NC2=O)/C2=CC=CC1=C(Cl)C=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.24 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight324.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.08mL | 15.4mL | 30.79mL |
| 5mM | 0.62mL | 3.08mL | 6.16mL |
| 10mM | 0.31mL | 1.54mL | 3.08mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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