Tocris抗体，试剂，血清，细胞 TOCRIS 4372-10MG,Tocris/SecinH3/2849/10/10 mg,球蛋白,天然蛋白,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/SecinH3/2849/10/10 mg

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Tocris Bioscience

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2849/10

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4000-520-616

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Description:Sec7-specificGEFinhibitor(cytohesins)

ChemicalName:N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Sec7-specificGEFinhibitorthatdisplaysselectivityforsmallGEFsofthecytohesinfamily(IC₅₀valuesare2.4,5.4,5.4,5.6,5.6,65and>100μMforhCyh4,hCyh1,mCyh3,hCyh3,drosophilasteppke,yGea2-S7andhEFA6-S7respectively).Inhibitsinsulinsignalingviainhibitionofinsulinreceptorsubstrateprotein(IRS)phosphorylation.

TechnicalData

M.Wt	460.5
Formula	C₂₄H₂₀N₄O₄S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	853625-60-2
PubChemID	1029232
InChIKey	QPGYAMIHXLCFTJ-UHFFFAOYSA-N
Smiles	O=C(CSC5=CC=CC=C5)NC(C=C4)=CC=C4N1C(C2=CC(OCO3)=C3C=C2)=NC(OC)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	46.05	100
	ethanol	4.61	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight460.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.17mL	10.86mL	21.72mL
5mM	0.43mL	2.17mL	4.34mL
10mM	0.22mL	1.09mL	2.17mL
50mM	0.04mL	0.22mL	0.43mL

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