BiologicalActivity
Potentp97ATPase(VCP)allostericinhibitor(IC50=30nM).SelectiveoverallotherAAAATPases,HSP90andkinasestested(IC50>10μM).Activatestheunfoldedproteinresponse(UPR)andmodulatesautophagosomematuration.Exhibitsantiproliferativeactivityincancercellsinvitro(IC50valuesare400and700nMforHCT116andHeLacellsrespectively).Reducesp97-sensitizationtotrypsindigestion.
TechnicalData
| M.Wt | 520.67 |
| Formula | C27H28N4O3S2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1418013-75-8 |
| PubChemID | 71521142 |
| InChIKey | UJGTUKMAJVCBIS-UHFFFAOYSA-N |
| Smiles | CC1=C(C2=CC=C(S(C)(=O)=O)C=C2)C=CC(OCC3=NN=C(N3C4=CN=CC=C4)SC5CCCC5)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.07 | 100 | |
| ethanol | 5.21 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight520.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.92mL | 9.6mL | 19.21mL |
| 5mM | 0.38mL | 1.92mL | 3.84mL |
| 10mM | 0.19mL | 0.96mL | 1.92mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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