BiologicalActivity
Potentinhibitorofcdk4/cyclinD1(IC50=59nM).AlsoactiveagainstCaMkinaseII(IC50=25nM)butdisplaysselectivityoverseveralotherkinasesinvitro(IC50valuesforinhibitionofPKAandPKCare>2and>100μMrespectively).Inhibitshumancytomegalovirus(HCMV)replicationinvitro(IC50=200nM).
CompoundLibraries
ArcyriaflavinAisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 325.32 |
| Formula | C20H11N3O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 118458-54-1 |
| PubChemID | 5327723 |
| InChIKey | KAJXOWFGKYKMMZ-UHFFFAOYSA-N |
| Smiles | O=C1NC(=O)C2=C1C1=C(NC3=CC=CC=C13)C1=C2C2=C(N1)C=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.53 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight325.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.07mL | 15.37mL | 30.74mL |
| 5mM | 0.61mL | 3.07mL | 6.15mL |
| 10mM | 0.31mL | 1.54mL | 3.07mL |
| 50mM | 0.06mL | 0.31mL | 0.61mL |
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