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Tocris/Atiprimod dihydrochloride/4580/10/10 mg
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4000-520-616
Description:JAK2inhibitor
ChemicalName:N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanaminedihydrochloride
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
JAK2inhibitor(IC50=397nM).AlsoinhibitsSTAT3andSTAT5phosphorylation.InhibitscellgrowthandinducesapoptosisincellsexpressingtheJAK2V617Fmutation.
TechnicalData
M.Wt | 409.52 |
Formula | C22H44N2.2HCl |
Storage | DesiccateatRT |
CASNumber | 130065-61-1 |
PubChemID | 166556 |
InChIKey | MOUZYBYTICOTFQ-UHFFFAOYSA-N |
Smiles | CCCC1(CCC)CCC2(CN(CCCN(CC)CC)CC2)CC1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 4.1 | 10mMwithgentlewarming | |
water | 20.48 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight409.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.44mL | 12.21mL | 24.42mL |
5mM | 0.49mL | 2.44mL | 4.88mL |
10mM | 0.24mL | 1.22mL | 2.44mL |
50mM | 0.05mL | 0.24mL | 0.49mL |
MolarityCalculator
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ReconstitutionCalculator
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DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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