Tocris公司代理生物计划正品Tocris Bioscience生物试剂1,Tocris/BAG 956/3606/50/50 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/BAG 956/3606/50/50 mg

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Tocris Bioscience

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3606/50

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4000-520-616

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Description:DualPI3-kinaseandPDPK1(PDK1)inhibitor

ChemicalName:α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DualPDPK1(PDK1)andclassIPI3-Kinhibitor(IC₅₀valuesare245,56,446,35and117nMforPDPK1andPI3-Kp110-α,-β,-δ,and-γrespectively).InhibitscellularAKTphosphorylationatThr308.Blockscellproliferation,causingarrestinG₁phaseofthecellcycle.Slowstumorprogressioninmousexenograftmodels.

CompoundLibraries

BAG956isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	427.5
Formula	C₂₈H₂₁N₅
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	853910-02-8
PubChemID	24882589
InChIKey	GVPAGJWVBUZHNQ-UHFFFAOYSA-N
Smiles	CC3=NC1=C(N3C4=CC=C(C(C)(C#N)C)C=C4)C2=C(C=CC(C#CC5=CN=CC=C5)=C2)N=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	17.1	40
	ethanol	8.55	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight427.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.34mL	11.7mL	23.39mL
5mM	0.47mL	2.34mL	4.68mL
10mM	0.23mL	1.17mL	2.34mL
50mM	0.05mL	0.23mL	0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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