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Tocris/Dexrazoxane hydrochloride/3857/10/10 mg
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4000-520-616
Description:TopoisomeraseIIinhibitor
AlternativeNames:ICRF-187
ChemicalName:4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
TopoisomeraseIIinhibitorandintracellularionchelator.BridgesandstABIlizesaninterfacebetweentwoATPasepromoterstoinhibittopoisomeraseIIactivity.Cardioprotectivewhenco-admiNISTeredwithdoxorubicin;decreasesformationofreactiveoxygenspecies(ROS)andactivatesthePI3K/Aktsurvivalpathway.
TechnicalData
M.Wt | 304.73 |
Formula | C11H16N4O4.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1263283-43-7 |
PubChemID | 6918223 |
InChIKey | BIFMNMPSIYHKDN-FJXQXJEOSA-N |
Smiles | C[C@@H](CN2CC(NC(C2)=O)=O)N(CC(N1)=O)CC1=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.47 | 100 | |
water | 30.47 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight304.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.28mL | 16.41mL | 32.82mL |
5mM | 0.66mL | 3.28mL | 6.56mL |
10mM | 0.33mL | 1.64mL | 3.28mL |
50mM | 0.07mL | 0.33mL | 0.66mL |
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ReconstitutionCalculator
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DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
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