BiologicalActivity
Potentandselectivep38α/βinhibitor(IC50valuesare26and102nM,respectively).Exhibits>100-foldselectivityforp38α/βover71otherkinases,enzymesandGPCRs,includingp38γ,p38δ,JNKandERK2.InhibitsLPS-inducedTNFαproductioninU937monocytesinvitro.Suppressesacuteandchronicinflammatoryresponsesinratmodelsofarthritis.Orallyactive.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc
TechnicalData
| M.Wt | 477.3 |
| Formula | C22H19BrF2N2O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1358027-80-1 |
| PubChemID | 22049997 |
| InChIKey | KCAJXIDMCNPGHZ-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(COC2=C(Br)C(N(C3=CC(C(NC)=O)=CC=C3C)C(C)=C2)=O)C(F)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.86 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight477.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.1mL | 10.48mL | 20.95mL |
| 5mM | 0.42mL | 2.1mL | 4.19mL |
| 10mM | 0.21mL | 1.05mL | 2.1mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
暂无品牌问答
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。