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Tocris/TC-E 5005/4572/50/50 mg
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Description:PotentandselectivePDE10Ainhibitor
ChemicalName:2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandselectivePDE10Ainhibitor(IC50valuesare7.28,239,779,919,3100and3700nMatPDE10A,2A,11A,5A,7Band3Arespectivelyand>5000nMatPDE1B,4A,6,8Aand9A).ReversesMK801-inducedhyperactivityinvivo.
TechnicalData
M.Wt | 270.33 |
Formula | C15H18N4O |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 959705-64-7 |
PubChemID | 24802717 |
InChIKey | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
Smiles | CC2=NC1=CC=C(OC)N=C1N3C2=C(C)N=C3CCC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.HCl | 27.03 | 100 | |
DMSO | 5.41 | 20 | |
ethanol | 27.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight270.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.7mL | 18.5mL | 36.99mL |
5mM | 0.74mL | 3.7mL | 7.4mL |
10mM | 0.37mL | 1.85mL | 3.7mL |
50mM | 0.07mL | 0.37mL | 0.74mL |
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ReconstitutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
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