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Tocris/YM 976/1821/50/50 mg
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Tocris/YM 976/1821/50/50 mg
品牌 / 
Tocris Bioscience
货号 / 
1821/50
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4000-520-616
Description:PDE4inhibitor
ChemicalName:4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

OrallyactivePDE4inhibitor(IC50=2.2nM).Lowemetogenicactivity,suggestedtobeduetopoorbrainpenetration.

CompoundLibraries

YM976isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt313.79
FormulaC17H16ClN3O
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber191219-80-4
PubChemID6604918
InChIKeyMNHXYNNKDDXKNP-UHFFFAOYSA-N
SmilesCCN1C(=O)N=C(C2=CC=CC(Cl)=C2)C2=C1N=C(CC)C=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.38100
ethanol31.38100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight313.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.19mL15.93mL31.87mL
5mM0.64mL3.19mL6.37mL
10mM0.32mL1.59mL3.19mL
50mM0.06mL0.32mL0.64mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet