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Tocris/Tadalafil/6311/50/50 mg
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4000-520-616
Description:PotentandhighlyselectivePDE5inhibitor;orallybioavailable
AlternativeNames:GF196960
ChemicalName:(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandhighlyselectivePDE5inhibitor(IC50=5nM).Exhibits>2000-foldselectivityforPDE5overPDEs1,2,3and4and1000-foldselectivityoverPDE6.Reducesbloodpressureinhypertensiverats.AlsodelaystumorgrowthinamousemodelviainhibitionofMDSC-mediatedimmunosuppression.Orallybioavailable.
TechnicalData
M.Wt | 389.4 |
Formula | C22H19N3O4 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 171596-29-5 |
PubChemID | 110635 |
InChIKey | WOXKDUGGOYFFRN-IIBYNOLFSA-N |
Smiles | [H][C@]12CC3=C([C@@H](C4=CC5=C(C=C4)OCO5)N1C(CN(C2=O)C)=O)NC6=CC=CC=C36 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 38.94 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight389.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.57mL | 12.84mL | 25.68mL |
5mM | 0.51mL | 2.57mL | 5.14mL |
10mM | 0.26mL | 1.28mL | 2.57mL |
50mM | 0.05mL | 0.26mL | 0.51mL |
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ReconstitutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
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