Enzyme | Target | Assay |
Kinase | ABL1s,ACK,AKTs,AMPKs,Auroras,AXL,BRK,BXM,CAMKs,CDKs,CyclinA2,DAPK1,EGFRs,ERKs,FAK,FGFR,FLT,GRK,GSKs,HER,HIPK,IKKs,JNKs,LYNB,MAPKAPK2/3/5,p38s,ROCKs,SLK,TNIK,ULK1,VRK2,ZAK,etal. | ADP-Glo |
Methyl-lysine | CBX1,L3MBTL1 | AlphaScreen/Fluorogenic |
Heatshockprotein | HSP90α,HSP90ß | AlphaScreen |
Deacetylases | HDAC1/2/3/4/5/6/7/8/9,SIRT1/2/3/5 | Fluorogenic |
PARPs | PARP1/2/3/6/7/10/11/14/15,TNKS1/S2 | Chemiluminescence/Colorimetric |
Protease | DPP3/4/7/8/9,FAP,POP,Renin,Caspase3/6/7/8 | Fluorogenic |
Phosphodiesterase | PDEs,Autotaxin | TR-FRET/FP/Fluorogenic |
Demethylases | FBXL10/11,JARID1A/B/C/D,JMJD1A,JMJD2s,JMJD3,LSD1,PHF8,TET1,TET2,UTX | AlphaScreen/Chemiluminescent |
Methyltransferases | DNMTs,DOT1L,EHMT1/GLP,EZHs,G9a,Histones,MLL1,NSDs,PRMTs,SetDB1,SUV39H,SMYDs,SETs,etal. | Chemiluminescence |
Bromodomains | ATADs,BAZ2B,BPTF/FALZ,BRD1/2/3/4/9,BRPF3,CECR2,CREBBP,BACE1,SMARCA2/4,BRG1,BRM,CBP,etal. | TR-FRET/AlphaScreen |
Immnotherapyrelated | ARG,CD,CTLA4,GITRL,IDO,MAT2A,NAMPT,PD-1,TDO,TIGIT,TPH,etal. | Colorimetric/Fluorogenic |
Others | COX,Myeloperoxidase,FAAH,FABP4,HAT,Lipoxygenase,PAD,PAFAcetylhydrolase,sPLA2(TypeV),PPARγ,etal. | FP/colorimetric/Fluorogenic |
