BiologicalActivity
Antidiabeticagent;bindstoPPARγandpotentlyinhibitsCdk5-mediatedPPARγphosphorylation(IC50=80nM;Ki=28.67nM)withoutexhibitingPPARγagoNISTactivity.DoesnotinhibitCdk5-dependentphosphorylationofRb.Reducesfastinginsulinlevelsandimprovesinsulinsensitivityinamousemodelofdiabetes.
CompoundLibraries
SR1664isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 547.6 |
| Formula | C33H29N3O5 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1338259-05-4 |
| PubChemID | 53239854 |
| InChIKey | IIJDFXNUWZTHIM-NRFANRHFSA-N |
| Smiles | CC2=C(C)N(CC3=CC=C(C4=CC=CC=C4C(O)=O)C=C3)C1=CC=C(C(N[C@H](C5=CC=C([N+]([O-])=O)C=C5)C)=O)C=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.76 | 100 | |
| ethanol | 54.76 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight547.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.83mL | 9.13mL | 18.26mL |
| 5mM | 0.37mL | 1.83mL | 3.65mL |
| 10mM | 0.18mL | 0.91mL | 1.83mL |
| 50mM | 0.04mL | 0.18mL | 0.37mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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