BiologicalActivity
ReversIBLeinhibitorofproteintranslocationfromtheendoplasmicreticulum(ER)totheGolgiapparatus.BlocksbindingofADP-ribosylationfactortotheGolgiapparatusandinhibitsGDP-GTPexchange.Canbeusedtoinduceautophagyinmammaliancells.AlsoenhancesCRISPR-mediatedhomology-directedrepair(HDR)efficiency~2-foldwhenappliedat100nM,inhumaninducedpluripotentstemcells(iPSCs).
CompoundLibraries
BrefeldinAisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 280.36 |
| Formula | C16H24O4 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 20350-15-6 |
| PubChemID | 6436187 |
| InChIKey | KQNZDYYTLMIZCT-KFKPYADVSA-N |
| Smiles | [H][C@]1(C)CCCC=CC2C[C@H](O)C[C@H]2[C@H](O)C=CC(=O)O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.02 | 50 | |
| ethanol | 2.8 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight280.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.57mL | 17.83mL | 35.67mL |
| 5mM | 0.71mL | 3.57mL | 7.13mL |
| 10mM | 0.36mL | 1.78mL | 3.57mL |
| 50mM | 0.07mL | 0.36mL | 0.71mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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