BiologicalActivity
PhotoswitchableNav,CavandKvchannelblocker.Blockschannelsinthetransconformation.Switchesconformationfromcistotransat500nmandtranstocisat380nm.Normallymembraneimpermeant,butentersnociceptiveneuronsviaionchannelsactivatedbynoxiousstimuli,particularlyTRPV1.ExhibitsopticallyreversIBLelocalanesthesiainrats.
TechnicalData
| M.Wt | 567.59 |
| Formula | C28H44Cl2N6O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 91826091 |
| InChIKey | VHURBRSYOFCHNY-UHFFFAOYSA-N |
| Smiles | O=C(C[N+](CC)(CC)CC)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-].[Cl-] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.68 | 10 | |
| water | 28.38 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight567.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.76mL | 8.81mL | 17.62mL |
| 5mM | 0.35mL | 1.76mL | 3.52mL |
| 10mM | 0.18mL | 0.88mL | 1.76mL |
| 50mM | 0.04mL | 0.18mL | 0.35mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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