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Tocris/Nanchangmycin/6183/10/10 mg

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Tocris Bioscience

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6183

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Description:Antiviral;activeagainstZika,WestNileanddengueviruses

ChemicalName:(2S,4R,6E,8S)-8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-Hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5-oxo-6-nonenoicacidsodiumsalt

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antiviral.InhibitsZikavirusentryinarangeofcelltypesincludingprimaryplacentalfibroblastcells,HUVECsandUtMECs(IC₅₀valuesare0.1,0.4and0.97μMinU2OS,HBMECsandJeg-3cellsrespectively).AlsoinhibitscellularuptakeofWestNile,dengue,sindbisandchikungunyaviruses.

TechnicalData

M.Wt	889.1
Formula	C₄₇H₇₇NaO₁₄
Storage	Storeat-20°C
CASNumber	65101-87-3
PubChemID	46930988
InChIKey	XMAIRYYXDCNFKP-DYTQFKGPSA-M
Smiles	[H][C@]1([C@]2(O[C@@](CO)([C@@H](C[C@@H]2C)C)O)[H])C[C@@H]([C@@]3(O[C@](C[C@@H]([C@H]3C)O[C@@]4(CC[C@@H]([C@H](O4)C)OC)[H])([C@@]5(CC[C@@]6(O5)C[C@@H]([C@H]([C@](O6)([C@H](/C=C(C([C@@H](C[C@@H](C(O[Na])=O)C)C)=O)C)C)[H])C)O)C)[H])O1)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	88.91	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight889.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.12mL	5.62mL	11.25mL
5mM	0.22mL	1.12mL	2.25mL
10mM	0.11mL	0.56mL	1.12mL
50mM	0.02mL	0.11mL	0.22mL

MolarityCalculator

Calculatethemass,volume,orconcentrationrequiredforasolution.

ReconstitutionCalculator

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

Volume(toaddtovial)

DilutionCalculator

Calculatethedilutionrequiredtoprepareastocksolution.

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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