BiologicalActivity
Antimalarialdrug.Inhibitscellgrowthandinducescelldeathinnumerouscancercelllines;inhibitscellproliferationandviABIlityandinducesapoptosisin4T1mousebreastcancercellsinvitro.Exhibitsantimetastaticactivity.Alsoinhibitsautophagyviaamechanismdistinctfromthatof3-methyladenine(Cat.No.3977).
TechnicalData
| M.Wt | 515.86 |
| Formula | C18H26ClN3·2H3PO4 |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 50-63-5 |
| PubChemID | 64927 |
| InChIKey | QKICWELGRMTQCR-UHFFFAOYSA-N |
| Smiles | CCN(CC)CCCC(C)NC2=CC=NC1=CC(Cl)=CC=C12.O=P(O)(O)O.O=P(O)(O)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 51.59 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight515.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.94mL | 9.69mL | 19.39mL |
| 5mM | 0.39mL | 1.94mL | 3.88mL |
| 10mM | 0.19mL | 0.97mL | 1.94mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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