BiologicalActivity
Selectiveinhibitoroferastininducedferroptosis(EC50=60nM).SpecificallyinhibitsRasselectivelethalcompound-induceddeath,butnotcelldeathinducedbyotheroxidativelethalcompoundsandapoptosis-inducingagents.Inhibitsferroptosisincancercells;alsoinhibitsglutamate-inducedcelldeathinorganotypicratbrainslices.Preventserastininducedaccumulationofcytosolicandlipidreactiveoxygenspecies.
CompoundLibraries
Ferrostatin1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 262.35 |
| Formula | C15H22N2O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 347174-05-4 |
| PubChemID | 4068248 |
| InChIKey | UJHBVMHOBZBWMX-UHFFFAOYSA-N |
| Smiles | O=C(OCC)C1=CC(N)=C(NC2CCCCC2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.23 | 100 | |
| ethanol | 26.23 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight262.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.81mL | 19.06mL | 38.12mL |
| 5mM | 0.76mL | 3.81mL | 7.62mL |
| 10mM | 0.38mL | 1.91mL | 3.81mL |
| 50mM | 0.08mL | 0.38mL | 0.76mL |
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