Tocris产品目录价格 Tocris Bioscience一级代理,Tocris/HA14-1/1541/50/50 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/HA14-1/1541/50/50 mg

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Tocris Bioscience

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1541/50

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4000-520-616

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Description:Bcl-2inhibitor.Inducesapoptosis

ChemicalName:2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Cell-permeableinhibitorofBcl-2protein(IC₅₀~9μM);actsbybindingtothesurfacepocket.DisruptsBax/Bcl-2interactionandinducesapoptosisoftumorcells.AlsobindstotheantiapoptoticBlc-2proteinsBcl-XLandBcl-w.

TechnicalData

M.Wt	409.23
Formula	C₁₇H₁₇BrN₂O₅
Storage	Desiccateat-20°C
CASNumber	65673-63-4
PubChemID	3549
InChIKey	SXJDCULZDFWMJC-UHFFFAOYSA-N
Smiles	CCOC(=O)C(C#N)C1C2=C(OC(N)=C1C(=O)OCC)C=CC(Br)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	40.92	100
	ethanol	40.92	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight409.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.44mL	12.22mL	24.44mL
5mM	0.49mL	2.44mL	4.89mL
10mM	0.24mL	1.22mL	2.44mL
50mM	0.05mL	0.24mL	0.49mL

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