BiologicalActivity
Ketaminemetabolite.EnhancesAMPAreceptor-mediatedexcitatorypost-synapticpotentialsintheCA1regionofhippocampalslices.DecreasesintracellularD-serine(aNMDAco-agonist)concentrationsinPC-12cells(IC50=0.68nM).Exertsantidepressanteffectsinmice.Lacksketamine-relatedsideeffects.
LicensingInformation
SoldunderlicensefromtheNIH,USpatent62/313,309
TechnicalData
| M.Wt | 276.16 |
| Formula | C12H14ClNO2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1430202-69-9 |
| PubChemID | 121513910 |
| InChIKey | ZQJVHBJDLMIKJK-MHDYBILJSA-N |
| Smiles | ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.62 | 100 | |
| water | 13.81 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight276.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.62mL | 18.11mL | 36.21mL |
| 5mM | 0.72mL | 3.62mL | 7.24mL |
| 10mM | 0.36mL | 1.81mL | 3.62mL |
| 50mM | 0.07mL | 0.36mL | 0.72mL |
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