BiologicalActivity
Anti-inflammatory,antioxidantandfreeradicalscavenger.InhibitsLPS-inducedTNF-α,IL-6andinducIBLenitricoxideproductionandblocksNF-κBandAP-1activation.AlsoinhibitsTNF-α-inducedCOX-2expression.Antiproliferativeandchemopreventative;inhibitsproliferationofLewislungcarcinomacellsinvivo.
TechnicalData
| M.Wt | 286.24 |
| Formula | C15H10O6 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 491-70-3 |
| PubChemID | 5280445 |
| InChIKey | IQPNAANSBPBGFQ-UHFFFAOYSA-N |
| Smiles | O=C(C=C(C3=CC(O)=C(O)C=C3)O2)C1=C2C=C(O)C=C1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 1.43 | 5 | |
| DMSO | 14.31 | 50 | |
| ethanol | 7.16 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight286.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.49mL | 17.47mL | 34.94mL |
| 5mM | 0.7mL | 3.49mL | 6.99mL |
| 10mM | 0.35mL | 1.75mL | 3.49mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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