Tocris试剂采购美国Tocris Bioscience公司,Tocris/MIM1/4762/50/50 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/MIM1/4762/50/50 mg

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Tocris Bioscience

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4762/50

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4000-520-616

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Description:Mcl-1inhibitor;proapoptotic

ChemicalName:4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofMcl-1;selectivelytargetstheBH3-bindingpocket.Inducescaspase-3/7activationandcelldeathinMcl-1-dependentleukemiacells.AlsoblocksMcl-1-mediatedsuppressionoftBID-inducedBaxactivationinvitro.

TechnicalData

M.Wt	347.43
Formula	C₁₇H₂₁N₃O₃S
Storage	Storeat+4°C
PubChemID	10205
InChIKey	VCMMXZQDRFWYSE-UHFFFAOYSA-N
Smiles	CC2=CS/C(N2/N=C/C3=CC=C(O)C(O)=C3O)=NC1CCCCC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	34.74	100
	ethanol	6.95	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight347.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.88mL	14.39mL	28.78mL
5mM	0.58mL	2.88mL	5.76mL
10mM	0.29mL	1.44mL	2.88mL
50mM	0.06mL	0.29mL	0.58mL

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