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Tocris/ML 311/5733/10/10 mg
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Description:InhibitsMcl-1-BIMinteraction
ChemicalName:7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
InhibitsMcl1-BIMinteraction.InhibitsviABIlityofMcl1-dependenttumorcelllines.InducescelldeathanddecreasedspheroidformationinHer2positivebreastcancercells.
TechnicalData
M.Wt | 415.45 |
Formula | C23H24F3N3O |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 315698-17-0 |
PubChemID | 3384730 |
InChIKey | NGAPBLRRJSKIRT-UHFFFAOYSA-N |
Smiles | CCN(CC1)CCN1C(C2=CC=C(C(F)(F)F)C=C2)C3=C(O)C4=NC=CC=C4C=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 20.77 | 50 | |
ethanol | 20.77 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight415.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.41mL | 12.04mL | 24.07mL |
5mM | 0.48mL | 2.41mL | 4.81mL |
10mM | 0.24mL | 1.2mL | 2.41mL |
50mM | 0.05mL | 0.24mL | 0.48mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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