BiologicalActivity
Potentinhibitorofmicrotubuleformation(IC50=1.5-3.4nM);inhibitspolymerizationoftubulininvitroanddisruptsmicrotubuleformationinseveralcancercelllines.Inhibitstumorgrowthinvitroandinvivo;exhibitspro-apoptoticcharacteristics.Brainpenetrant.
CompoundLibraries
MPC6827hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 315.8 |
| Formula | C17H17N3O.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 917369-31-4 |
| PubChemID | 11638255 |
| InChIKey | VYUWDIKZJLOZJL-UHFFFAOYSA-N |
| Smiles | CC2=NC1=CC=CC=C1C(N(C)C3=CC=C(OC)C=C3)=N2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.58 | 100 | |
| water | 31.58 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight315.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.17mL | 15.83mL | 31.67mL |
| 5mM | 0.63mL | 3.17mL | 6.33mL |
| 10mM | 0.32mL | 1.58mL | 3.17mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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