Tocris批发，产品货源 Tocris GPCR ligands,Tocris/NDT 9513727/3333/50/50 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/NDT 9513727/3333/50/50 mg

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Tocris Bioscience

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3333/50

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Description:Potent,selectivehumanC5areceptorantagoNIST

ChemicalName:N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentC5areceptor(C5aR)competitiveantagonist(IC₅₀=11.6nM);selectiveforhumanC5aR(IC₅₀valuesforratandmouseC5aRare>10μM).Exhibitsinverseagonistpharmacokinetics.BlocksdegranulationresponseinC5a-stimulatedU937cells(IC₅₀=7.1nM).Orallybioavailable.

CompoundLibraries

NDT9513727isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	573.68
Formula	C₃₆H₃₅N₃O₄
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	439571-48-9
PubChemID	10210160
InChIKey	ITACCRHKSPSKKL-UHFFFAOYSA-N
Smiles	CCCCN1C(C6=CC=CC=C6)=NC(C7=CC=CC=C7)=C1CN(CC3=CC(OCO5)=C5C=C3)CC2=CC=C(OCO4)C4=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	57.37	100
	ethanol	57.37	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight573.68.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.74mL	8.72mL	17.43mL
5mM	0.35mL	1.74mL	3.49mL
10mM	0.17mL	0.87mL	1.74mL
50mM	0.03mL	0.17mL	0.35mL

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