Tocris产品促销 Tocris离子通道调控剂,Tocris/Necrosulfonamide/5025/50/50 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Necrosulfonamide/5025/50/50 mg

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Tocris Bioscience

货号 /

5025/50

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4000-520-616

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Description:Necroptosisinhibitor

ChemicalName:(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Necroptosisinhibitor.Blocksmixedlineagekinasedomain-likeprotein(MLKL),acriticalsubstrateofreceptor-interactingserine-threoninekinase3(RIP3)duringnecrosis.PreventsMLKL-RIP1-RIP3necrosomecomplexfrominteractingwithdownstreamnecrosiseffectors.

TechnicalData

M.Wt	461.47
Formula	C₁₈H₁₅N₅O₆S₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1360614-48-7
PubChemID	1566236
InChIKey	FNPPHVLYVGMZMZ-XBXARRHUSA-N
Smiles	O=C(NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2)/C=C/C1=CC=C([N+]([O-])=O)S1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	9.23	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight461.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.17mL	10.83mL	21.67mL
5mM	0.43mL	2.17mL	4.33mL
10mM	0.22mL	1.08mL	2.17mL
50mM	0.04mL	0.22mL	0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

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