Tocris试剂产品信息 Tocris Bioscience授权代理商，正品,Tocris/Nogo-66 (1-40)/1984/1/1 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Nogo-66 (1-40)/1984/1/1 mg

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Tocris Bioscience

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1984/1

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Description:CompetitiveantagoNISTforNogo-66receptor;promotesneuronregeneration

AlternativeNames:NEP1-40,NogoExtracellularPeptide,1-40

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Peptidefragmentcorrespondingtoresidues1-40ofNogo-66,thedomainofthemyelinproteinNogothatinhibitsaxonaloutgrowth.ActsasacompetitiveantagonistattheNogo-66receptor(NgR);blocksNogo-66-andCNSmyelin-inducedinhibitionofaxonalgrowth,butdoesnotreducemyelin-associatedglycoprotein(MAG)inhibitionofneuriteoutgrowthinvitro.Promotesregenerationofhemisectedspinalaxonsandlocomotorrecoveryfollowingspinalinjuryinvivo.

TechnicalData

M.Wt	4625.16
Formula	C₂₀₆H₃₂₄N₅₆O₆₅
Sequence	RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS (Modifications:Arg-1=N-terminalAc,Ser-40=C-terminalamide)
Storage	Desiccateat-20°C
CASNumber	475221-20-6
PubChemID	16142739
InChIKey	OLEKMOOQFWTQGD-SJQNMCRDSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	Solubleto1mg/mlinwater

Solubility

Solubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4625.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.22mL	1.08mL	2.16mL
5mM	0.04mL	0.22mL	0.43mL
10mM	0.02mL	0.11mL	0.22mL
50mM	0mL	0.02mL	0.04mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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