Tocris型号参数规格 TOCRIS 4372-10MG,Tocris/Rotenone/3616/50/50 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Rotenone/3616/50/50 mg

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Tocris Bioscience

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3616/50

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4000-520-616

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Description:InhibitscomplexIofthemitochondrialelectrontransportchain

ChemicalName:(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Mitochondrialelectrontransportchaininhibitor(IC₅₀=1.7-2.2μMatcomplexI).InhibitsNADHoxidationbycardiacsarcoplasmicreticulum(IC₅₀=3.4nM).CommonlyusedpesticideandinducesParkinsonisminanimalmodels.Mayalsoinhibitautophagyinduction;blockslysosomaldegradationofautophagicvacuoles.Cell-permeableandbrainpenetrant.

TechnicalData

M.Wt	394.42
Formula	C₂₃H₂₂O₆
Storage	StoreatRT
Purity	≥95%(HPLC)
CASNumber	83-79-4
PubChemID	6758
InChIKey	JUVIOZPCNVVQFO-HBGVWJBISA-N
Smiles	C=[C@](C)[C@@H](C5)OC4=C5C(O3)=C(C=C4)C([C@@]([C@@]3([H])CO2)([H])C1=C2C=C(OC)C(OC)=C1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	39.44	100
	ethanol	1.97	5

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight394.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.54mL	12.68mL	25.35mL
5mM	0.51mL	2.54mL	5.07mL
10mM	0.25mL	1.27mL	2.54mL
50mM	0.05mL	0.25mL	0.51mL

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BiologicalActivity

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SolubilityData

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