BiologicalActivity
HighaffinityandselectiveactivatorofBax(Ki=43.3nM).BindstotheS184bindingpockettoblockBaxphosphorylation.DoesnotbindtootherBcl-2familymembers,includingBcl-2,BakandBid.FacilitatesBaxinsertionintothemitochondrialmembraneandpromotesBax-dependentcytochromecrelease.InducesapoptosisinlungcancercelllinesexpressinghighlevelsofBaxselectivelyovernormalcellsexpressinglowlevelsofBax.RepressestumorgrowthofA549lungcancerxenograftsinmice.
TechnicalData
| M.Wt | 315.32 |
| Formula | C20H13NO3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 906440-37-7 |
| PubChemID | 349156 |
| InChIKey | PEYKRJBXACUOOB-UHFFFAOYSA-N |
| Smiles | OC(C=CC=C4)=C4C=C2C3=C(C=CC([N+]([O-])=O)=C3)C1=CC=CC=C1/2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.53 | 100 | |
| ethanol | 3.15 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight315.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.17mL | 15.86mL | 31.71mL |
| 5mM | 0.63mL | 3.17mL | 6.34mL |
| 10mM | 0.32mL | 1.59mL | 3.17mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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