Tocris中国采购 Tocris配体,Tocris/PF 429242/3354/10/10 mg,转录表达,克隆和表达,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PF 429242/3354/10/10 mg

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Tocris Bioscience

货号 /

3354/10

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4000-520-616

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Description:CompetitiveinhibitorofSREBPsite1protease

ChemicalName:4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ReversIBLe,competitiveinhibitorofsterolregulatoryelement-bindingprotein(SREBP)site1protease(IC₅₀=0.175μM).Selectiveforsite1proteaseagainstapanelofserineproteases.InhibitsrateofcholesterolsynthesisinCHOcells(IC₅₀=0.53μM).Alsodisplaysantiviralactivity.Cellpermeable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

PF429242isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	482.49
Formula	C₂₅H₃₅N₃O₂.2HCl
Storage	DesiccateatRT
Purity	≥97%(HPLC)
CASNumber	947303-87-9
PubChemID	90488837
InChIKey	GSUZWFZKTIOWTI-MQWQBNKOSA-N
Smiles	O=C(C2=CC=C(CN(CC)CC)C=C2)N(CCC3=CC=CC=C3OC)[C@@H]1CCNC1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	24.12	50
	ethanol	48.25	100
	water	24.12	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight482.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.07mL	10.36mL	20.73mL
5mM	0.41mL	2.07mL	4.15mL
10mM	0.21mL	1.04mL	2.07mL
50mM	0.04mL	0.21mL	0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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