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Tocris/Apelin-36 (human)/2426/1/1 mg

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Tocris Bioscience

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2426/1

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4000-520-616

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Description:EndogenousAPJreceptoragoNIST

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

EndogenousAPJreceptoragonist(EC₅₀=20nM)thatissecretedbyADIpocytes.BindswithhighaffinitytohumanAPJreceptorsexpressedinHEK293cells(pIC₅₀=8.61).Involvedinregulationofcardiovascularfunction,fluidhomeostasisandfeeding.BlocksentryofsomeHIV-1andHIV-2strainsintoNP-2/CD4cellsexpressingAPJ.

TechnicalData

M.Wt	4195.87
Formula	C₁₈₄H₂₉₇N₆₉O₄₃S
Sequence	LVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
Storage	Desiccateat-20°C
CASNumber	252642-12-9
PubChemID	25023576
InChIKey	IRSHPNNQNFBJMK-ZWVJBCNTSA-N
Smiles	[H]N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	Solubleto1mg/mlinwater

Solubility

Solubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4195.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.24mL	1.19mL	2.38mL
5mM	0.05mL	0.24mL	0.48mL
10mM	0.02mL	0.12mL	0.24mL
50mM	0mL	0.02mL	0.05mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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