BiologicalActivity
HistamineH3receptorinverseagonist(EC50=1.5nM)andantagonist(Ki=0.16nM).Exhibitsnootropiceffectsincognitivedisorders;reduceslocomotorhyperactivityinducedbymethamphetamine.Brainpenetrant.
CompoundLibraries
BF2649hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 332.31 |
| Formula | C17H26ClNO.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 903576-44-3 |
| PubChemID | 11551689 |
| InChIKey | XLFKECRRMPOAQS-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.23 | 100 | |
| ethanol | 33.23 | 100 | |
| water | 33.23 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight332.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.01mL | 15.05mL | 30.09mL |
| 5mM | 0.6mL | 3.01mL | 6.02mL |
| 10mM | 0.3mL | 1.5mL | 3.01mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |
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