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Tocris/CID 2745687/4293/50/50 mg
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4000-520-616
Description:GPR35antagoNIST
ChemicalName:1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylicacidmethylester
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Competitive,reversIBLeantagonistoftheorphanreceptorGPR35(Ki=12.8nM).BlockstheGPR35-mediatedincreaseinERK1/2phosphorylationandβ-arrestinrecruitmentinducedbypamoicacid(Cat.No.4298).
CompoundLibraries
CID2745687isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 395.43 |
Formula | C17H19F2N5O2S |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 264233-05-8 |
PubChemID | 9581011 |
InChIKey | CYNLZIBKERMMOA-AWQFTUOYSA-N |
Smiles | FC1=CC(F)=CC=C1N2C(/C=N/NC(NC(C)(C)C)=S)=C(C(OC)=O)C=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.54 | 100 | |
ethanol | 3.95 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight395.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.53mL | 12.64mL | 25.29mL |
5mM | 0.51mL | 2.53mL | 5.06mL |
10mM | 0.25mL | 1.26mL | 2.53mL |
50mM | 0.05mL | 0.25mL | 0.51mL |
MolarityCalculator
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Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
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DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
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