BiologicalActivity
ActivemetaboliteofvitaminD3thatactivatesthevitaminDreceptor(VDR).Displayscalcemicactions;stimulatesintestinalandrenalCa2+absorptionandregulatesboneCa2+turnover.Exhibitsantitumoractivity;inhibitsinvivoandinvitrocellproliferationinawiderangeofcellsincludingbreast,prostate,colon,skinandbraincarcinomasandmyeloidleukemiacells.
TechnicalData
| M.Wt | 416.64 |
| Formula | C27H44O3 |
| Storage | Desiccateat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 32222-06-3 |
| PubChemID | 5280453 |
| InChIKey | GMRQFYUYWCNGIN-NKMMMXOESA-N |
| Smiles | C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(C)O)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)C1=C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | SolubleinDMSOandinethanol |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight416.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.4mL | 12mL | 24mL |
| 5mM | 0.48mL | 2.4mL | 4.8mL |
| 10mM | 0.24mL | 1.2mL | 2.4mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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