BiologicalActivity
HighaffinityandselectiveGPERreceptorantagonist(Ki=20nM)thatdisplaysnoaffinityforERαandERβatconcentrationsupto10μM.Inhibitsagonist-inducedcalciummobilizationinvitro(EC50of~185nM)andantagonizestheantidepressiveandrenoprotectiveeffectsofestrogeninvivo.
TechnicalData
| M.Wt | 370.24 |
| Formula | C19H16BrNO2 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1161002-05-6 |
| PubChemID | 90488870 |
| InChIKey | LBBDCJLRQXMUAE-FWHYVADDSA-N |
| Smiles | BrC1=CC4=C(OCO4)C=[C@@]1[C@@H]2NC(C=CC=C5)=C5[C@@]3([H])[C@@]([H])2CC=C3.BrC6=CC9=C(OCO9)C=[C@@]6[C@H]7NC(C=CC=C%10)=C%10[C@]8([H])[C@]([H])7CC=C8 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.51 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight370.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.7mL | 13.5mL | 27.01mL |
| 5mM | 0.54mL | 2.7mL | 5.4mL |
| 10mM | 0.27mL | 1.35mL | 2.7mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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