Tocris产品促销 Tocris信号通路抑制剂,Tocris/GRI 977143/4779/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/GRI 977143/4779/10/10 mg

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Tocris Bioscience

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4779/10

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4000-520-616

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Description:SelectiveLPA₂receptornon-lipidagoNIST

ChemicalName:2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectivelysophosphatidicacid2(LPA₂)receptornon-lipidagonist(EC₅₀=3.3μM).DoesnotactivateotherLPAGPCRsatconcentrationsupto10μM.Antiapoptotic;inhibitsactivationofcaspases3,7,8and9,BaxtranslocationandPARP-1cleavage.ActivatesERK1/2survivalpathway.

TechnicalData

M.Wt	391.44
Formula	C₂₂H₁₇NO₄S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	325850-81-5
PubChemID	3114900
InChIKey	GMVZUCHUOYUMLL-UHFFFAOYSA-N
Smiles	O=C(C2=CC=CC3=CC=CC(C4=O)=C23)N4CCCSC1=CC=CC=C1C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	39.14	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight391.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.55mL	12.77mL	25.55mL
5mM	0.51mL	2.55mL	5.11mL
10mM	0.26mL	1.28mL	2.55mL
50mM	0.05mL	0.26mL	0.51mL

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