BiologicalActivity
Selective,non-steroidalfarnesoidXreceptor(FXR)agonist(EC50=15nM).Displaysnoactivityatothernuclearreceptorsatconcentrationsupto1μM.Improveshyperglycaemiaandhyperlipidemiaindiabeticdb/dbmice.Showntosuppressautophagyinnutrient-deprivedmousehepatocytes.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
TechnicalData
| M.Wt | 542.84 |
| Formula | C28H22Cl3NO4 |
| Storage | Desiccateat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 278779-30-9 |
| PubChemID | 9893571 |
| InChIKey | BYTNEISLBIENSA-MDZDMXLPSA-N |
| Smiles | CC(C)C1=C(COC2=CC(Cl)=C(C=CC3=CC=CC(=C3)C(O)=O)C=C2)C(=NO1)C1=C(Cl)C=CC=C1Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.3 | 100 | |
| ethanol | 5.43 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight542.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.84mL | 9.21mL | 18.42mL |
| 5mM | 0.37mL | 1.84mL | 3.68mL |
| 10mM | 0.18mL | 0.92mL | 1.84mL |
| 50mM | 0.04mL | 0.18mL | 0.37mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
暂无品牌问答
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。