BiologicalActivity
Novel,lowpotencyCB2receptorsilentantagonistandCB1receptorpartialinverseagonist.CompetitivelyantagonizeseffectsofCP55,940(pA2=6.1)andSR144528(pEC50=5.3)atCB2receptorsandactsasapartialinverseagonistatCB1receptors(pIC50=5.5).DisplaysmodestactivityathumanmelatoninMT1andmuscarinicM4receptors,butisselectiveoverseveralotherGPCRs.
TechnicalData
| M.Wt | 522.61 |
| Formula | C27H26N2O3.CH3SO3H |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 131543-25-4 |
| PubChemID | 11613341 |
| InChIKey | FSGCSTPOPBJYSX-BDQAORGHSA-N |
| Smiles | CS(O)(=O)=O.CC1=C(C(=O)C2=CC=CC3=C2C=CC=C3)C2=CC=CC3=C2N1[C@@H](CN1CCOCC1)CO3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.26 | 100mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight522.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.91mL | 9.57mL | 19.13mL |
| 5mM | 0.38mL | 1.91mL | 3.83mL |
| 10mM | 0.19mL | 0.96mL | 1.91mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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