BiologicalActivity
Broadspectrumsteroidreceptorligand;bindswithhighaffinitytomineralocorticoidreceptors(Ki=39nM)andloweraffinitytoprogesterone,androgenandglucocorticoidreceptors(Kivaluesare201,240and224nMrespectively).FunctionsprimarilyasanantagoNISTofthesereceptors,withtheexceptionoftheprogesteronereceptorwhereitdisplayspartialagonisteffects.Alsoexertshypolipidemicactivity,likelyviaantagonismofthereceptorforbileacids(farnesoidXreceptor;FXR).
TechnicalData
| M.Wt | 312.45 |
| Formula | C21H28O2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 95975-55-6 |
| PubChemID | 146898 |
| InChIKey | WDXRGPWQVHZTQJ-NRJJLHBYSA-N |
| Smiles | [H][C@@]12CC(=O)C(=CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 3.12 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight312.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.2mL | 16mL | 32.01mL |
| 5mM | 0.64mL | 3.2mL | 6.4mL |
| 10mM | 0.32mL | 1.6mL | 3.2mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |
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