BiologicalActivity
PotentandhighlyselectivehistamineH3receptoragonist(pEC50=9.74)thatdisplays300-foldselectivityovertheH4receptor(pKivaluesare9.07and6.61respectively).DoesnotbindtoH1orH2receptorsatconcentrationsupto10μM. .
TechnicalData
| M.Wt | 321.01 |
| Formula | C9H9N3.2HBr |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 699020-93-4 |
| PubChemID | 16759172 |
| InChIKey | CYNKWHIKNDIVDR-UHFFFAOYSA-N |
| Smiles | Br.Br.C(C1=CN=CN1)C1=CC=NC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.1 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight321.01.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.12mL | 15.58mL | 31.15mL |
| 5mM | 0.62mL | 3.12mL | 6.23mL |
| 10mM | 0.31mL | 1.56mL | 3.12mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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