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Tocris/LY 255283/2208/10/10 mg
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Description:Selective,competitiveBLT2receptorantagoNIST
ChemicalName:1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Selective,competitiveantagonistofBLT2receptors(IC50valuesare~1and>10μMathumanrecombinantBLT2andBLT1receptorsrespectively).InhibitsLTB4-inducedcontractionoflungparenchyma(pA2=7.2),andreducesLTB4-mediatedairwayobstructioninguineapigsfollowingi.v.andoraladministration. .
CompoundLibraries
LY255283isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 360.46 |
Formula | C19H28N4O3 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 117690-79-6 |
PubChemID | 122023 |
InChIKey | WCGXJPFHTHQNJL-UHFFFAOYSA-N |
Smiles | CCC1=C(OCCCCCC(C)(C)C2=NN=NN2)C=C(O)C(=C1)C(C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 36.05 | 100 | |
ethanol | 9.01 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight360.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.77mL | 13.87mL | 27.74mL |
5mM | 0.55mL | 2.77mL | 5.55mL |
10mM | 0.28mL | 1.39mL | 2.77mL |
50mM | 0.06mL | 0.28mL | 0.55mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
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DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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